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PROJECTS MicroRNAs & ncRNAs Regulatory mechanisms and interactions of non-protein-coding RNAs Non-protein-coding RNAs (ncRNA) have been shown to be involved in important aspects of gene regulation, including chromatin silencing, alternative splicing, RNA editing, mRNA cleavage and translational suppression. This project will try to elucidate regulatory mechanisms involving ncRNA molecules, and in particular microRNA (miRNA), by using a combination of bioinformatic and experimental approaches. Zebrafish will be used as a model system for testing predictions from bioinformatic analyses This is a collaborative project between NTNU and the Sars International Centre for Marine Molecular Biology and the Computational Biology Unit at the University of Bergen (UoB). Here at NTNU, we will focus on developing novel computational algorithms for miRNA gene and target prediction as well as for general ncRNA gene discovery. Our methods include robust machine learning algorithms such as boosting and support vector machines. The roles of microRNAs and transcription factors in gene regulation and tissue specific expression MicroRNAs (miRNAs) are important genes that regulate many aspects of animal development, including cell growth, cell differentiation, and cell death, and aberrant miRNA expression levels characterize many diseases, ranging from various cancers to heart disorders and mental illnesses. Many miRNAs seem to have tissue-specific expression patterns, which suggest that together with transcription factors, miRNAs may be crucial for establishing and maintaining tissue specific gene regulation. These mechanisms are currently poorly understood, however. By combining bioinformatic and experimental approaches, this project will try to elucidate how miRNAs and transcription factors coordinately regulate genes. The project will focus on three problems: cell-cycle regulation, cell-type specific gene expression in rat brains, and aberrant miRNA expression during virus infections. Tools References
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Bioinformatics & Gene Regulation Department of Cancer Research and Molecular Medicine Norwegian University of Science and Technology Trondheim, Norway |