Using custom generated positional priors to improve motif discovery with MEME

Combined results from all 22 datasets

Track	Sn	Sp	PPV	ASP	PC	F	Acc	CC	sSn
Uniform	0.073	0.988	0.069	0.071	0.037	0.071	0.978	0.06	0.084
Conservation	0.175	0.991	0.182	0.178	0.098	0.178	0.981	0.169	0.229
Combined_priors	0.267	0.992	0.278	0.272	0.158	0.272	0.983	0.264	0.325

Dataset: M00621 - C/EBP delta

Track	Sn	Sp	PPV	ASP	PC	F	Acc	CC	sSn
Uniform	0	0.989	0	0	0	0	0.978	-0.011	0
Conservation	0	0.989	0	0	0	0	0.978	-0.011	0
Combined_priors	0.051	0.99	0.055	0.053	0.03	0.052	0.979	0.042	0.06

Dataset: M00622 - C/EBP gamma

Track	Sn	Sp	PPV	ASP	PC	F	Acc	CC	sSn
Uniform	0	0.972	0	0	0	0	0.929	-0.036	0
Conservation	0	0.972	0	0	0	0	0.929	-0.036	0
Combined_priors	0.015	0.964	0.025	0.02	0.01	0.019	0.922	-0.02	0.03

Dataset: M00658 - PU.1

Track	Sn	Sp	PPV	ASP	PC	F	Acc	CC	sSn
Uniform	0	0.988	0	0	0	0	0.98	-0.01	0
Conservation	0.583	0.995	0.467	0.525	0.35	0.519	0.992	0.518	0.667
Combined_priors	0.377	0.992	0.279	0.328	0.207	0.313	0.987	0.314	0.408

Dataset: M00699 - ICSBP (IRF8)

Track	Sn	Sp	PPV	ASP	PC	F	Acc	CC	sSn
Uniform	0.317	0.987	0.238	0.277	0.157	0.271	0.979	0.264	0.4
Conservation	0.2	0.988	0.171	0.186	0.102	0.185	0.978	0.174	0.4
Combined_priors	0.237	0.988	0.205	0.221	0.127	0.219	0.979	0.209	0.42

Dataset: M00733 - SMAD4

Track	Sn	Sp	PPV	ASP	PC	F	Acc	CC	sSn
Uniform	0	0.977	0	0	0	0	0.956	-0.023	0
Conservation	0	0.98	0	0	0	0	0.958	-0.021	0
Combined_priors	0.217	0.988	0.301	0.259	0.145	0.251	0.971	0.241	0.317

Dataset: M00764 - HNF-4 direct repeat 1

Track	Sn	Sp	PPV	ASP	PC	F	Acc	CC	sSn
Uniform	0	0.987	0	0	0	0	0.976	-0.012	0
Conservation	0.154	0.992	0.182	0.168	0.091	0.167	0.982	0.158	0.2
Combined_priors	0	0.989	0	0	0	0	0.978	-0.011	0

Dataset: M00771 - Ets

Track	Sn	Sp	PPV	ASP	PC	F	Acc	CC	sSn
Uniform	0	0.99	0	0	0	0	0.978	-0.011	0
Conservation	0.286	0.996	0.429	0.357	0.207	0.343	0.988	0.344	0.429
Combined_priors	0.314	0.995	0.409	0.361	0.216	0.35	0.987	0.349	0.429

Dataset: M00774 - NF-kB

Track	Sn	Sp	PPV	ASP	PC	F	Acc	CC	sSn
Uniform	0	0.984	0	0	0	0	0.974	-0.013	0
Conservation	0.333	0.995	0.417	0.375	0.227	0.37	0.988	0.367	0.556
Combined_priors	0.474	0.994	0.426	0.45	0.351	0.445	0.988	0.442	0.494

Dataset: M00797 - HIF1 (hypoxia induced factor)

Track	Sn	Sp	PPV	ASP	PC	F	Acc	CC	sSn
Uniform	0	0.981	0	0	0	0	0.966	-0.017	0
Conservation	0.305	0.988	0.285	0.295	0.173	0.295	0.977	0.283	0.364
Combined_priors	0.294	0.988	0.281	0.288	0.173	0.286	0.977	0.275	0.323

Dataset: M00799 - MYC

Track	Sn	Sp	PPV	ASP	PC	F	Acc	CC	sSn
Uniform	0	0.985	0	0	0	0	0.979	-0.01	0
Conservation	0	0.985	0	0	0	0	0.979	-0.01	0
Combined_priors	0.054	0.987	0.033	0.043	0.024	0.041	0.981	0.033	0.062

Dataset: M00809 - FOX factors

Track	Sn	Sp	PPV	ASP	PC	F	Acc	CC	sSn
Uniform	0	0.994	0	0	0	0	0.986	-0.007	0
Conservation	0	0.995	0	0	0	0	0.988	-0.006	0
Combined_priors	0	0.994	0	0	0	0	0.987	-0.007	0

Dataset: M00920 - E2F

Track	Sn	Sp	PPV	ASP	PC	F	Acc	CC	sSn
Uniform	0	0.987	0	0	0	0	0.977	-0.012	0
Conservation	0.052	0.991	0.057	0.054	0.028	0.054	0.982	0.045	0.062
Combined_priors	0.1	0.991	0.109	0.105	0.08	0.104	0.982	0.095	0.112

Dataset: M00929 - MyoD

Track	Sn	Sp	PPV	ASP	PC	F	Acc	CC	sSn
Uniform	0	0.988	0	0	0	0	0.973	-0.013	0
Conservation	0.093	0.989	0.111	0.102	0.053	0.101	0.976	0.089	0.167
Combined_priors	0.23	0.992	0.301	0.266	0.155	0.259	0.981	0.253	0.358

Dataset: M00965 - DR4 (direct repeat 4)

Track	Sn	Sp	PPV	ASP	PC	F	Acc	CC	sSn
Uniform	0	0.99	0	0	0	0	0.978	-0.011	0
Conservation	0	0.99	0	0	0	0	0.978	-0.011	0
Combined_priors	0.051	0.993	0.097	0.074	0.035	0.066	0.982	0.061	0.11

Dataset: M00978 - LEF1, TCF1

Track	Sn	Sp	PPV	ASP	PC	F	Acc	CC	sSn
Uniform	0	0.976	0	0	0	0	0.961	-0.02	0
Conservation	0	0.988	0	0	0	0	0.973	-0.014	0
Combined_priors	0.119	0.983	0.092	0.105	0.056	0.104	0.97	0.089	0.15

Dataset: M00982 - KROX

Track	Sn	Sp	PPV	ASP	PC	F	Acc	CC	sSn
Uniform	0.571	0.995	0.533	0.552	0.381	0.552	0.991	0.548	0.636
Conservation	0.377	0.993	0.352	0.364	0.222	0.364	0.987	0.358	0.455
Combined_priors	0.484	0.994	0.437	0.46	0.311	0.459	0.989	0.454	0.55

Dataset: M00983 - MAF

Track	Sn	Sp	PPV	ASP	PC	F	Acc	CC	sSn
Uniform	0.568	0.995	0.625	0.597	0.424	0.595	0.988	0.59	0.625
Conservation	0.625	0.992	0.529	0.577	0.401	0.573	0.986	0.568	0.625
Combined_priors	0.68	0.993	0.604	0.642	0.472	0.638	0.988	0.634	0.694

Dataset: M01007 - SRF (serum response factor)

Track	Sn	Sp	PPV	ASP	PC	F	Acc	CC	sSn
Uniform	0	0.985	0	0	0	0	0.976	-0.012	0
Conservation	0	0.984	0	0	0	0	0.975	-0.012	0
Combined_priors	0.779	0.996	0.698	0.739	0.651	0.736	0.994	0.734	0.785

Dataset: M01011 - HNF-1

Track	Sn	Sp	PPV	ASP	PC	F	Acc	CC	sSn
Uniform	0	0.992	0	0	0	0	0.978	-0.011	0
Conservation	0.361	0.996	0.583	0.472	0.287	0.446	0.987	0.453	0.583
Combined_priors	0.347	0.995	0.528	0.438	0.265	0.418	0.986	0.421	0.525

Dataset: M01035 - YY1

Track	Sn	Sp	PPV	ASP	PC	F	Acc	CC	sSn
Uniform	0	0.992	0	0	0	0	0.983	-0.008	0
Conservation	0	0.994	0	0	0	0	0.985	-0.007	0
Combined_priors	0.05	0.992	0.051	0.051	0.027	0.051	0.984	0.043	0.092

Dataset: M01036 - COUPTF

Track	Sn	Sp	PPV	ASP	PC	F	Acc	CC	sSn
Uniform	0	0.992	0	0	0	0	0.979	-0.01	0
Conservation	0	0.988	0	0	0	0	0.975	-0.012	0
Combined_priors	0.078	0.993	0.127	0.103	0.054	0.095	0.981	0.089	0.13

Dataset: M01067 - Gfi1

Track	Sn	Sp	PPV	ASP	PC	F	Acc	CC	sSn
Uniform	0	0.99	0	0	0	0	0.981	-0.01	0
Conservation	0	0.99	0	0	0	0	0.981	-0.01	0
Combined_priors	0.117	0.992	0.114	0.116	0.062	0.115	0.985	0.108	0.15