Modeling regulatory complexes using both TF-DNA and TF-TF interactions|
Department of Computer Science, University of Helsinki, Finland
Transcription factors (TFs) not only bind to DNA but also to each other. The individual interactions between TFs are often weak. However, the complexes
formed by both TF-DNA and TF-TF interactions are much more stable than those based on similar TF-DNA interactions alone. Thus, the dimerization mediated by DNA
gives a much richer regulatory machinery that has a potentially stronger capability to explain the regulation of gene expression. The talk will describe recent
developments in modeling and predicting such regulatory complexes, using data from high-throughput SELEX experiments, and applying this to explain observed binding
patterns in DNA.