Modeling regulatory complexes using both TF-DNA and TF-TF interactions Esko Ukkonen Department of Computer Science, University of Helsinki, Finland |
Transcription factors (TFs) not only bind to DNA but also to each other. The individual interactions between TFs are often weak. However, the complexes
formed by both TF-DNA and TF-TF interactions are much more stable than those based on similar TF-DNA interactions alone. Thus, the dimerization mediated by DNA
gives a much richer regulatory machinery that has a potentially stronger capability to explain the regulation of gene expression. The talk will describe recent
developments in modeling and predicting such regulatory complexes, using data from high-throughput SELEX experiments, and applying this to explain observed binding
patterns in DNA.
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